The brain is shielded from potentially toxic substances by the presence of a barrier. The Blood Brain Barrier (BBB) is an anatomical interface that separates the brain from the circulatory system. The endothelial cells of the blood vessels, perivascular cells (pericytes), astrocytes and neurons from teh neurovascular unit
and regulate effective functioning of the CNS.
Notes:
Small lipid-doluble melecules <400Da can cross the BBB via lipid-mediated diffusion
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